Review of ultrasensitive readout for micro-/nanofluidic devices by thermal lens microscopy
نویسندگان
چکیده
Thermal lens microscopy (TLM) utilizes the effects, such as changes in refractive index, caused by heat generated sample for detection of nonfluorescent analytes with at least a hundred-fold enhancement sensitivity compared optical absorbance spectrometry. Micro-/nanofluidic devices can provide specificity and manipulation capabilities. The integration these two technologies exposes potential to attain holy grail continuous, real-time, label-free, specific, ultrasensitive detection, which find applications environmental monitoring, quality control chemical manufacturing, single-cell analysis, biomedicines. Here, we summarize recent advances instrument development innovative applications, suggest future directions research TLM.
منابع مشابه
Micro/Nanofluidic Devices for Single Cells Analysis
1 Institute of Nano Engineering and Microsystems, National Tsing Hua University, Kuang Fu Road, No. 101, Section 2, Hsinchu 30013, Taiwan; E-Mail: [email protected] 2 Department of Engineering and System Science, National Tsing Hua University, Kuang Fu Road, No. 101, Section 2, Hsinchu 30013, Taiwan 3 Division of Mechanics, Research Center for Applied Sciences, Academia Sinica, Nankang, 11...
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ژورنال
عنوان ژورنال: Journal of optical microsystems
سال: 2021
ISSN: ['2708-5260']
DOI: https://doi.org/10.1117/1.jom.1.2.020901